Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The paper attempts to provide a basis for exploring the continued relevance of Catholic social teaching to business ethics, byinterpreting the historic development of a Catholic work ethic and the traditions of Catholic social teaching in light of contemporary discussions of economic globalization, notably those of Robert Reich and Peter Drucker. The paper argues that the Catholic work ethic and the Church’s tradition of social teaching has evolved dynamically in response to the structural changes involved in the history of modern (...) economic development, and thus is well poised to speak to the ethical challenges implicit in the advent of a knowledge-based society. In order to test this thesis, the author sketches an approach to the ethical challenge of corporate downsizing that he believes illustrates the continued relevance of Catholic social teaching to business ethics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Bonaventure's Aesthetics: The Delight of the Soul in Its Ascent into God by Thomas J. McKennaDennis P. BrayThomas J. McKenna, Bonaventure's Aesthetics: The Delight of the Soul in Its Ascent into God. Lanham, Maryland: Lexington Books, 2020. 186 pp. $100. ISBN: 978-1-4985-9765-4.It has been just over three decades since the last book-length engagement with aesthetics in Bonaventure's work (S. McAdams, "The Aesthetics of Light: A Critical Examination of (...) Bonaventure's Doctrine of Light in View of His Aesthetics," [PhD diss., Pontifica Universitas Gregoriana, 1991]). Heartily welcome, then, is Thomas McKenna's Bonaventure's Aesthetics. The purpose of the book, in McKenna's words, is "to provide a comprehensive analysis of Bonaventure's aesthetics, that is, his philosophy, theology, and mystical theology" (2). In so doing, he intends also to argue for a resolution to a list of disputed questions raised by contemporary voices – most famously that of Balthasar – in the debate on Bonaventure's aesthetics. Put another way, McKenna's project has two aims: first, to understand Bonaventure's aesthetics on its own (historical, theological, philosophical) terms; second, to determine whether that aesthetic connects significantly to contemporary questions in the field of aesthetics. In this review I will detail and engage critically with some of the foundational methodological moves McKenna makes in the book's introduction. I will then summarize the big themes of the book's four chapters, and conclude with a few evaluative remarks.However extensive their merits, earlier studies on Bonaventure's aesthetics are not as thorough as McKenna's and, more problematically, are limited by their investment in predominantly Enlightenment-era concerns. What I mean is that thinkers such as Shaftesbury, Baumgarten, and Kant were absorbed with matters such as the immediacy of the aesthetic experience, disinterest, the role of the affect, freedom of the imagination, and the categorization of les beaux arts. It is this trajectory (call it "the standard paradigm," using McKenna's terminology) that the field of aesthetics, as we know it, has largely followed. Early historians of aesthetics viewed, and often evaluated, medievals through the standard paradigm. Even later, more revisionist historical work sought to understand medieval thought in distinction from the paradigm. In most instances, [End Page 243] though, it is the Enlightenment-era list of concerns that serves as the fulcrum on which historical work has tended to swing. Our understanding of Bonaventure, then, is limited to the extent that we take the standard paradigm as guide.Bonaventure's Aesthetics is so compelling, in part, because it does not begin with the standard paradigm, but rather a more historically sound (and frankly, more interesting) list of research questions. This is not to say that McKenna rejects the standard paradigm. It is simply too deeply embedded in how we conceive of such matters to naively ignore. Instead, McKenna works to situate these later concerns as secondary, or parallel, to Bonaventure's concerns and interests. McKenna realizes that he faces a difficulty at this juncture, one that must be addressed by anyone aiming for historical sensitivity regarding their object of study. The difficulty is what McKenna calls "the hermeneutical crisis," and he formulates the key issues by quoting Jean Grondin: "The basic doctrine…is that every particular phenomenon must be conceptualized within the context of its age" to avoid anachronism. But if so, this "raises a striking epistemological problem…Our view of earlier ages must itself be produced by reference to our present, and is thereby relativized." Thus Grondin asks, "how if at all, is it possible to escape from the hermeneutic circle of our historicity?" (9, quoting J. Grondin, Introduction to Philosophicaal Hermeneutics [New Haven: Yale University Press, 1997], 76).Restricted to Bonaventure studies, McKenna poses the worry this way: "is it possible to accurately recover the conceptualization of beauty and, perhaps, the arts of any age – ancient, medieval, or modern – with a reasonable degree of accuracy? If so, does it remain relevant to current aesthetic theory and practice?" (9).In sum, the apparent dilemma is between, on the one hand, "a historically accurate conceptualization of the aesthetic sympathies of the past," and on the other hand, "a... (shrink)

The author considers the issue of what it is for a health care institution to be intentionally Christian. He begins with a review of Catholic social teaching, and considers how this perspective is shaping Catholic thought and action regarding health care management and public policy reform. He then proposes some standards for intentionally Christian institutions.

Ernst Troeltsch's essay on socialism presents a summary account of his views on the prospects for a socialist economic order within the Weimar Republic. Troeltsch attempts to formulate a compromise that incorporates the proposals of both social conservatism and communism. Such a compromise, he insists, is possible on the basis of a realistic assessment of socialism supported by "an act of faith in the future" based upon explicitly religious resources. This essay is significant not only in relation to the "religious (...) socialism" then discussed in Germany, but also for the development of "political theology" today. (shrink)

As interpreted by Pattee, von Neumann’s Theory of Self-Reproducing Automata has proved to be a useful tool for understanding some of the difficulties and paradoxes of molecular biosemiotics. But is its utility limited to molecular systems or is it more generally applicable within biosemiotics? One way of answering that question is to look at the Theory as a model for one particular high-level biosemiotic activity, human language. If the model is not useful for language, then it certainly cannot be generally (...) useful to biosemiotics. Beginning with the Universal Turing Machine and continuing with von Neumann’s Theory and Pattee’s interpretation, the properties of universality, programmability, underspecification, complementarity of description/construction, and open-ended evolutionary potential are shown to be usefully applicable to language, thus opening a new line of inquiry in biosemiotics. (shrink)

Chinese philosophers today are challenged to make sense of faith in God, and particularly Christian faith as expressed by Chinese Christians, as an existential affirmation centering their personal and social lives. I offer here a philosophical approach to Christian faith, based upon interpretations of Søren Kierkegaard's work, Sickness unto Death. Kierkegaard's phenomenology of Christian conversion helps us understand and evaluate the recently obtained testimonies of 37 Hong Kong Chinese Christian business executives. Our study reveals not only what Christian faith means (...) to our informants, but also how Kierkegaard's interpretations are helpful in attempting a philosophical analysis of their testimonies. (shrink)

This book presents a view of the concepts in the Kantian scheme of things. The author attempts to show that Kant has not established the necessity of thinking human freedom in the theoretical sphere as would seem to be demanded by the inner logic of the first Critique and by the concept of autonomy in the second Critique.

The paper attempts to provide a basis for exploring the continued relevance of Catholic social teaching to business ethics, by interpreting the historic development of a Catholic work ethic and the traditions of Catholic social teaching in light of contemporary discussions of economic globalization, notably those of Robert Reich and Peter Drucker. The paper argues that the Catholic work ethic and the Church's tradition of social teaching has evolved dynamically in response to the structural changes involved in the history of (...) modern economic development, and thus is well poised to speak to the ethical challenges implicit in the advent of a knowledge-based society. In order to test this thesis, the author sketches an approach to the ethicalchallenge of corporate downsizing that he believes illustrates the continued relevance of Catholic social teaching to business ethics. (shrink)

This essay explores the imaginative foundations of ethics, not by presenting a theory about the moral imagination, but by reconstructing the hermeneutic strategy underlying Reinhold Niebuhr's proposal for "an independent Christian ethic." The thesis is that Niebuhr's ethic cannot adequately be evaluated without careful attention to his hermeneutics, what he described as "the mythical method of interpretation." This point is argued first, by reconstructing Niebuhr's hermeneutics; second, by showing how his hermeneutics determines the strategy of his ethics; and third, by (...) using this focus to clarify certain issues separating Niebuhr and some of his recent critics, specifically, William Frankena's criticism of his metaethics, Gene Outka's objections to his normative ethic of love as self-sacrifice; and John Howard Yoder's rejection of the strategy of his Christian realism as a whole. The essay is presented in the hope that Niebuhr's example will encourage American religious ethicists to explore the relationship between hermeneutics and ethics with greater intellectual sympathy and theoretical sophistication. The example of Niebuhr's "independent Christian ethic" is commended as one attempt to map the formal and substantive ways in which religious visions help shape our dispositions and moral choices. (shrink)

The paper is a response to Richard De George's essay, Theological Ethics and Business Ethics. It defends the possibility of theologically oriented approaches to business ethics by pointing out certain deficiencies in business ethics narrowly based on the premisses of analytic moral philosophy. In particular it argues, in a manner consistent with Alasdair MacIntyre's After Virtue (1981), that such a program of business ethics is insufficiently critical of its own roots in the social fiction of bureaucratic rationality. After showing how (...) this ideology governs De George's negative judgments on theological approaches to business ethics, the author outlines a program of critical reflection that would draw from the intellectual traditions of both theology and philosophy in order to facilitate a dialogue in business ethics that no longer is captive in the Iron Cage of bureaucratic rationality. (shrink)

For the past five years at the Daniels College of Business at the University of Denver a community service or service learning component has been included in the Values in Action class (now Values-Based Leadership), a core MBA course that integrates ethics, law, and public policy perspectives on business issues. This paper summarizes the educational philosophy and the mechanics of this required component. Few empirical studies have been conducted to gauge the perceived value and impact of a service learning requirement (...) on students. Thus, several surveys were conducted to understand better the choices made by students as well as the impact of the requirement on students. Preliminary results reveal generally a positive effect on students, including some evidence that such a service learning requirement may influence students to make a greater lifetime commitment to community service. (shrink)

This paper documents the types and amounts of aid exchanged between adults and their non-coresidential parents. Data for the study are drawn from a representative national sample survey of Americans age 19 and older conducted in 1987–1988. Exchanges of monetary and material resources, childcare, household assistance, and companionship and advice are considered.Patterns of intergenerational exchange are found to differ by gender, family structure, age, ethnicity, and socioeconomic situation. Differences in exchange between males and females and between whites and Mexican-Americans are (...) related to other life-course characteristics, and to the availability and proximity of kin. Blacks and persons living in poverty are shown to be less involved than other groups in intergenerational exchanges. Finally, patterns of prior assistance and the available needs and resources of the respondents and their parents are found to influence current patterns of exchange. (shrink)

Does Christian faith matter in business? If so, how does it affect the way executives handle managerial issues, especially the ones that are ethically controversial? This paper reports a study of Chinese Christian executives in Hong Kong. The researchers followed an approach known as the Critical Incident Technique and conducted in-depth interviews with 119 Chinese Christian executives over a two year period from 1999 to 2001. Each interview covered four broad areas consisting of the interviewee''s description of his or her (...) Christian faith, business experience, reported critical incidents and general remarks on faith and work. For each reported critical incident, the interviewee deliberated on the incident and its background, his or her response, the rationale behind the response and its consequences. Each interview was tape recorded for transcription and analysis. The major contribution of this study is to propose and document a typology of the executives'' responses to ethical challenges in business. The typology is based on earlier work on Christ and culture and styles of negotiation. Preliminary research findings indicate that the proposed typology is an effective paradigm. It has the promise of enabling Christian executives to reflect critically on their ethical behavior and to guide their thought towards more effective responses to ethical challenges. (shrink)

The paper attempts to provide a basis for exploring the continued relevance of Catholic social teaching to business ethics, byinterpreting the historic development of a Catholic work ethic and the traditions of Catholic social teaching in light of contemporary discussions of economic globalization, notably those of Robert Reich and Peter Drucker. The paper argues that the Catholic work ethic and the Church’s tradition of social teaching has evolved dynamically in response to the structural changes involved in the history of modern (...) economic development, and thus is well poised to speak to the ethical challenges implicit in the advent of a knowledge-based society. In order to test this thesis, the author sketches an approach to the ethical challenge of corporate downsizing that he believes illustrates the continued relevance of Catholic social teaching to business ethics. (shrink)

Einstein regarded as one of the triumphs of his 1915 theory of gravity - the general theory of relativity - that it vindicated the action-reaction principle, while Newtonian mechanics as well as his 1905 special theory of relativity supposedly violated it. In this paper we examine why Einstein came to emphasise this position several years after the development of general relativity. Several key considerations are relevant to the story: the connection Einstein originally saw between Mach's analysis of inertia and both (...) the equivalence principle and the principle of general covariance, the waning of Mach's influence owing to de Sitter's 1917 results, and Einstein's detailed correspondence with Moritz Schlick in 1920. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:OBJECTIVITY AND RELlGIOUS TRUTH: A COMPARISON OF WILFRED CANTWELL SMITH AND BERNARD LONERGAN DENNIS M. DOYLE University of Dayton Dayton, Ohio WILFRED CANTWELL SMITH •and Bernard Lonergan both propose a new agenda for theology n response to ;the same basic cultura.I developments.1 Both Smith and Lonergan pinpoint the crux of the current siturution!aJS the convergence of various cultures in a world where Western culture had.been heM (...) by its pwrticiipants to be univers•al.and normrutive. The majo'l" problem concerning religious truth :that 1 arises out of this situation concerns universality. Formulrutions tha:t were once taken for granted are now seen to he relative to their context. Concepts that it.T1anscend particular formulations are themselves recognized irus indigenous to 1a culture. T·ruth itself is questioned as to whether it too is not!l'elative to eaich oontert. The responses of Smith and Lonergan to this situa:tion are remarkably ·similar in structure. In the midst of these similarities, 1 however, arise some differences with important implications concerning oibjectivity, itruth, and theology in a global context. Objec:tivity, Method, and Human Knowledge Smith and Lonergan both 'address rthe issue of human knowing before establishing their programs for theo1 logy.2 For botih, 1 Smith's proposal is put forth in Towards a World Theology (Phila.: Westminster Press, 1981 )• Lonergan's proposal can be found in Method in Theology (N.Y.: Herder and Herder, 1972). 2 Smith's reflections on human knowing are in "Objectivity and the Humane Sciences,'' in Towards a World Theology, pp. 56·80'. Lonergan's 461 462 DENNIS M. DOYLE a major problem in wayis of conceiving human knowing in recent centuries has heen an ohjectivism according to which knowledge was iheld to he absolute without regard to human SUJbjectivity and without an openness to other cultures. Both find a £acile cultural remtivism to he.an unsatisfactory reaction to this problem. In response, :both Smith and Lonergan try to re-root human knowing in a human conte:rl. Lonergan does ·this hy establishing the ground of knowing in an analysis of human intentionality. Smith does this by estaiblishing the ground of knowing in a mutual interchange between persons who participate in some traditions and who are observers of other traditions. Smith la.bels such knowing ·a" 001·iporaite critica1 self-iconsciousness." What emerges from such consciousness is "humane knowledge." Although some major di:ffevences arise at this point, the context of istructul'lal similarities must he noted.3 For hoth Smith and Lonergan, hruman knowing is intrinsically connected with :the quality of living both individually and oommullla1ly. Eiach in his own way stresses that knowing is vitally linked to the consciousness of individuals. Each in his own way stresses that knowing takes place within ·community, and that the breadth and quality of the community affects the breadth and quality of the knowing. Smith •and Lonergan both, furthermore, envision the taisk of theology as the conceptualization and articulation in a new context of wihat was once known in a strictly objective, theoretical f:vame;work. Both, finailily, 'lay ouit the major work on human knowing is Insight: A Study of Human Understo;nding (N.Y.: Philosophical Library, 1957). For a summary view, see chapter one of Method in Theology. For Lonergan's position on objectivity, see "The Origins of Christian Realism" in A Second Collection (Phila.: Westminster Press, 1974), ·pp. 239-61. a For an earlier comparison of the methods of Smith and Lonergan, see Walter E. Conn, "'Faith' and 'Cumulative Tradition' in Functional Specialization : A Study in the Methodologies of Wilfred Cantwell Smith and Bernard Lonergan," Studies in ReligiOn/Soiences Religieuses 5 (1975/76) : 221-46•.Although this article was published before several of Smith's major works in the area, the methodological similarities unearthed by Conn still hold true. WILFRED CANTWELL SMITH & BERNARD LONERGAN 463 problem specifically in terms of tmnscending false subject/object :dichotomies. At this point, however, differences between Smith and Lonwgian begin to emerge, foir each attempts to transcend false.suibjoot/oibject dichotomies in a different way. Lonergan holds that objectivity is the fruit of authentic ;subjectivity.4 1t is intended hy the self-transcending subject who loves... (shrink)

This paper explores the possibility that causal decision theory can be formulated in terms of probabilities of conditionals. It is argued that a generalized Stalnaker semantics in combination with an underlying branching time structure not only provides the basis for a plausible account of the semantics of indicative conditionals, but also that the resulting conditionals have properties that make them well-suited as a basis for formulating causal decision theory. Decision theory (at least if we omit the frills) is not an (...) esoteric science, however unfamiliar it may seem to an outsider. Rather it is a systematic exposition of the consequences of certain well-chosen platitudes about belief, desire, preference and choice. It is the very core of our common-sense theory of persons, dissected out and elegantly systematized. (David Lewis, Synthese 23:331–344, 1974, p. 337). A small distortion in the analysis of the conditional may create spurious problems with the analysis of other concepts. So if the facts about usage favor one among a number of subtly different theories, it may be important to determine which one it is. (Robert Stalnaker, A Defense of Conditional Excluded Middle, pp. 87–104, 1980, p. 87). (shrink)

Vann McGee has proposed a counterexample to the Ramsey Test. In the counterexample, a seemingly trustworthy source has testified that p and that if not-p, then q. If one subsequently learns not-p, then one has reason to doubt the trustworthiness of the source and so, the argument goes, one has reason to doubt the conditional asserted by the source. Since what one learns is that the antecedent of the conditional holds, these doubts are contrary to the Ramsey Test. We argue (...) that the counterexample fails. It rests on a principle of testimonial dependence that is not applicable when a source hedges his or her claims. (shrink)

Back injuries have a bad reputation. The workman looks upon them with apprehension, the insurance company with doubt, the medical examiner with suspicion, the lawyer with uncertainty. The medical examiner is faced with the difficulty of estimating the true value of the subjective symptoms in the comparative absence of physical signs. His suspicion is born of the frequent disparity between these two. This prophetic statement made almost 100 years ago highlights an ongoing problem - how people who are incapacitated by (...) painful conditions such as chronic low back pain can be evaluated consistently and equitably for purposes of disability compensation. We confronted this vexing problem when we participated in writing the chapter devoted to impairment associated with pain of the American Medical Association s Guides to the Evaluation of Permanent Impairment, 5th edition AMA Guides 5th Our purposes in this essay are to clarify several important conceptual issues associated with the assessment of pain among disability applicants, and to articulate reasons why pain should be considered in impairment and disability ratings. (shrink)

Classic studies of explanation, such as those of Hempel and Bromberger, took it for granted that an explanation-seeking question of the form "Why P?" should be understood as asking about the proposition P. This view has been recently challenged by Bas van Fraassen and Alan Garfinkel. They acknowledge that some questions have the surface form "Why P?", but they hold that a correct reading for why-questions should take the form "Why P (rather than Q)?", where Q is a contrasting alternative. (...) This contrast theory is discussed here. It is argued that, properly understood, the contrast theory and the propositional approach can and should give equivalent readings to why-questions. (shrink)

This guide accompanies the following article(s): ‘Full Disclosure of the “Raw Data” of Research on Humans: Citizens’ Rights, Product Manufacturer’s Obligations and the Quality of the Scientific Database.’Philosophy Compass 6/2 (2011): 90–99. doi: 10.1111/j.1747‐9991.2010.00376.x Author’s Introduction Securing consent (and informed consent) from patients and research study participants is a key concern in patient care and research on humans. Yet, the legal doctrines of consent and informed consent differ in their applications. In patient care, the judicial doctrines of consent and informed (...) consent are disclosure doctrines based on the obligation of physicians to inform their patients of the following types of information: the nature of the procedure the physician is recommending in the patent’s care (P), the alternatives to the physician‐recommendation (A), and the risks of procedure and its alternatives (R). In addition, the physician must provide truthful answers to the patient’s questions (Q) to the best of the physician’s abilities. In research on humans, the onus of disclosure by study sponsors and principal investigators is much greater than in patient care precisely because the purpose of research is not patient care. The purpose of research is the identification and development of new generalizable knowledge. Thus, participation in a research study or trial may not benefit the study volunteer at all. In addition, the participant may carry a heavy risk burden in relationship to any testing of a newly designed drug or device as part of their experiences in the research study. Presently, despite the risks borne by the research study participant, the raw data collected from volunteers in research trials are treated by courts as if they were the private property of the study sponsor rather than generally owed to the public as would be expected by an effort like research participation aimed at contributing to the development of generalizable knowledge. This paper reviews the obligations that study sponsors owe to their study participants based on the very definition of research as a systematic activity whose purpose is to develop generalizable knowledge to help all humans. Author Recommends Court cases Canterbury v. Spence, United States Court of Appeals, District of Columbia Circuit 464 F.2d 772 (1972). (Federal appellate decision heard in the District of Columbia, USA) Reibl v. Hughes, 2 S.C.R. 880 (1980). (Supreme Court of Canada) Rogers v. Whitaker, 175 C.L. R. 479 (1992). (High Court of Australia) Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985) (House of Lords) Canterbury v. Spence is the landmark Federal informed consent case in the United States heard in the District of Columbia. In this case, Judge Spottswood Robinson articulated the reasonable person standard of informed consent. This standard was subsequently adopted by the Supreme Court of Canada (Reibl v. Hughes, 2 S.C.R. 880 (1980)) and the High Court of Australia (Rogers v. Whitaker, 175 C.L. R. 479 (1992)). The House of Lords rejected the reasonable person standard in England in Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985). Book Mazur, Dennis J. The Science and Ethics of Research on Humans. Baltimore, MD: Johns Hopkins University Press, 2007. This book is a detailed guide for the review of scientific and ethical aspects of research on humans contained in the research study protocols and research informed consent forms which need to be submitted by study sponsors and principal investigators to institutional review boards (IRBs) for IRB review before a research study can receive approval to be conducted within a human study population in those institutions over which the IRB has authority. It also presents basic definitions in the area of research on humans and basic approaches to help conduct a deep review of the underlying scientific and ethical issues that are present within a research study protocol and its accompanying research informed consent form. Report National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Guidelines for the Protection of Human Subjects of Research. Washington, DC: DHEW Publications, 1978 (78‐0012). This U.S. National Commission in the Belmont Report argued for the necessity of a reasonable volunteer standard in research on humans in the United States. Arguing that the professional standard and the reasonable person standard of consent and informed consent were insufficient to base a disclosure standard in research on humans, this National Commission developed the reasonable volunteer standard where a study participant is to be approached in research informed consent with that information that a reasonable volunteer would want to know. Online Materials Belmont Report: Syllabus Topics for Lecture and Discussion Week I: Introduction and Overview Readings: Rogers v. Whitaker, 175 C.L.R. 479 (1992). (High Court of Australia) Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985) (House of Lords) Week II: The Different Standards of Consent and Informed Consent Readings: Canterbury v. Spence, 464 F.2d 772 (1972). (Federal appellate opinion heard in the District of Columbia) Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985) (House of Lords) Week III: Definition of Research Reading: Mazur, Dennis J. The Science and Ethics of Research on Humans. Baltimore, MD: Johns Hopkins University Press, 2007. (Especially Chapters 2 and 3) Week IV: How to Review a Research Study Protocol and Research Informed Consent Form Reading: Mazur, Dennis J. The Science and Ethics of Research on Humans. Baltimore, MD: Johns Hopkins University Press, 2007. (Especially Chapters 4–6, 10, and 12–14) Week V: Obligations in Research of Humans Versus Patient Care Reading: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Guidelines for the Protection of Human Subjects of Research. Washington, DC: DHEW Publications, 1978 (78‐0012). Focus Questions • How do the judicial doctrines of consent in England and Australia compare to the judicial doctrines of informed consent in the United States and Canada? • How does a professional standard of disclosure differ from a reasonable person standard of disclosure? • What is the definition of research? • How is a research study (study proposal and research informed consent form) reviewed from scientific and ethical bases for considerations of approval by an IRB? • How do the obligations of a study sponsor, a principal investigator, and a research team conducting a research trial on human study participants differ from the obligations of a physician caring for a patient? • Should all raw data of research derived from humans be made available to the public for use in developing generalizable knowledge to help others, or should raw data be considered the private property of the study sponsors (for example, prescription drug manufacturers), who fund the research trials? Seminar/project Idea Draw a timeline of the development of the basic concepts of consent and informed consent in patient care and in patient research. On this timeline, first place the dates of the key court cases in England, the United States, Canada, and Australia on consent and informed consent. Then place the date of the development of the Belmont Report. Why do differences exist between these four countries in terms of the legal requirements of informedness of a patient (in medical care) and a study participant (in medical research)? What roles if any do the concepts of self‐determination and self‐decision have in consent and informed consent in patient care and in informed consent in research on humans among the four countries of interest? What are the realities of research on human participants that require a new standard of informed consent, the reasonable volunteer standard, to be developed beyond the two standards in patient care, the professional standard, and the reasonable person standard? Counterpoint Arguments The following are counterpoint arguments that need to be appreciated to more fully understand the concepts that impact the thesis that ‘raw data’ should be open to the public to allow the opportunity of checking of the results of its associated scientific paper and for further analysis. De‐Identified (Anonymized) Raw Data A current approach to identifying (anonymizinig) raw data is based on the Health Insurance Portability and Accountability Act (HIPAA) of 1996 (P.L.104‐191). HIPAA was enacted by the U.S. Congress in 1996 to keep a person’s medical information private. In a research study, a person’s private medical information can become research data. HIPAA’s Privacy Rule allows a covered entity to de‐identify data by removing all 18 elements that could be used to identify the individual or the individual’s relatives, employers, or household members; these elements are enumerated in the Privacy Rule. The covered entity must also have no actual knowledge that the remaining information could be used alone or in combination with other information to identify the individual who is the subject of the information. Under this method, the identifiers that must be removed are the following: 1 Names. 2 All geographic subdivisions smaller than a state, including street address, city, county, precinct, ZIP Code, and their equivalent geographical codes, except for the initial three digits of a ZIP Code if, according to the current publicly available data from the Bureau of the Census: 2a. The geographic unit formed by combining all ZIP Codes with the same three initial digits contains more than 20,000 people. 2b. The initial three digits of a ZIP Code for all such geographic units containing 20,000 or fewer people are changed to 000. 3 All elements of dates (except year) for dates directly related to an individual, including birth date, admission date, discharge date, and date of death, and all ages over 89 and all elements of dates (including year) indicative of such age, except that such ages and elements may be aggregated into a single category of age 90 or older. 4 Telephone numbers. 5 Facsimile numbers. 6 Electronic mail addresses. 7 Social security numbers. 8 Medical record numbers. 9 Health plan beneficiary numbers. 10 Account numbers. 11 Certificate/license numbers. 12 Vehicle identifiers and serial numbers, including license plate numbers. 13 Device identifiers and serial numbers. 14 Web universal resource locators (URLs). 15 Internet protocol (IP) address numbers. 16 Biometric identifiers, including fingerprints and voiceprints. 17 Full‐face photographic images and any comparable images. 18 Any other unique identifying number, characteristic, or code, unless otherwise permitted by the Privacy Rule for re‐identification. Even though ‘raw data’ can be de‐identified (anonymized) so that there is no way to trace back the data to the study participant from which it was drawn, there are still questions whether the ‘de‐identified raw data’ can be given to other researchers or made public without the original study participant’s approval. It may be the case that this approval could be done at the start of any research study where the individual considering study participation would be counseled on what the process of de‐identification consists of and would be asked whether the participant would allow use of the data by other researchers or made available to the public in a de‐identified state. However, there may be questions of the study participants as to whether the data are truly de‐identified and untraceable back to the study participant since the participant would not be able to see the process actually being carried out in detail in all relevant circumstances. Using Raw Data in Context Simply being in possession of raw data is never enough to build on that data from a research perspective. Researchers need to understand the context of the scientific research study in which the data were collected. This research context includes (but is not limited to): (i) the scientific hypothesis of the research study, (ii) the inclusion and exclusion criteria selected by the research designers of the study to determine which study participants were included and which were excluded from the study, (iii) the methods used to collect the data and possibilities of errors in the data collection processes, and (iv) answers to questions regarding whether any data were excluded from the study data and why these data were excluded. Ownership Rights Over Data There are ownership rights over data. Ownership rights include court decision making related to the question which parties are to be considered as the owners of the data. Possible owners here include (but are not limited to) (i) the study sponsor whose only role was to fund that study, (ii) the principal investigator(s) who developed the scientific hypothesis, and (iii) individual study participants through special contracts made by individual participants who negotiate such contracts with study sponsors and principal investigators to share in the ownership of data. Examples of such data are participant sources of unique gene lines or unique cell lines to be used in future research. Objections to Data Sharing Finally, individual researchers may simply object to sharing data. A researcher’s arguments here may be simply stating that he or she has a right to fully analyze the data since the collection of the data was the researchers’ idea in the first place. These researchers may argue that they have the right to mine the data as fully as they can before deciding to make the data open to the public for others to analyze. Works Cited 1 Kaiser, J. ‘Making Clinical Data Widely Available.’Science 322.5899 (10 Oct. 2008): 217–8. 2 de Lusignan, S., J.F. Metsemakers, P. Houwink, V. Gunnarsdottir, and J. van der Lei. ‘Routinely Collected General Practice Data: Goldmines for Research? A Report of the European Federation for Medical Informatics Primary Care Informatics Working Group (EFMI PCIWG) from MIE2006, Maastricht, The Netherlands.’Informatics in Primary Care 14.3 (2006): 203–9. 3 Sim, I. ‘Human Studies Database Project’, CTSA Data Repositories Symposium (17 Oct. 2008). 23 Nov. 2010. 4 Sim, I., C.G. Chute, H. Lehmann, R. Nagarajan, M. Nahm, and R.H. Scheuermann. ‘Keeping Raw Data in Context.’Science 323.5915 (6 Feb. 2009): 713. 5 U.S. Department of Health and Human Services, National Institutes of Health, HIPAA Privacy Rule, Information for Researchers. 13 Nov. 2010. 6 Wilczynski, N.L., R.B. Haynes, and Hedges Team. ‘EMBASE Search Strategies for Identifying Methodologically Sound Diagnostic Studies for Use by Clinicians and Researchers.’BMC Medicine 29.3 (March 2005): 7. (shrink)

Suppose for reductio that I know a proposition of the form <p and I don’t know p>. Then by the factivity of knowledge and the distribution of knowledge over conjunction, I both know and do not know p ; which is impossible. Propositions of the form <p and I don’t know p> are therefore unknowable. Their particular kind of unknowability has been widely discussed and applied to such issues as the realism debate. It hasn’t been much applied to theories of (...) the nature of knowledge. That is what I’m going to do here. (shrink)

THE ESSAY "OF MIRACLES," IN ADDITION TO BEING ONE OF THE MOST PROVOKING SECTIONS OF HUME’S WRITINGS, IS ALSO ONE OF THE MOST WIDELY MISUNDERSTOOD. HUME CLAIMS HIS ARGUMENT IS SIMILAR TO AN ARGUMENT OF ARCHBISHOP TILLOTSON, AND I EXPLORE THE PARALLEL BETWEEN THE TWO ARGUMENTS IN DETAIL. FUNDAMENTAL TO BOTH IS THE CONCEPT OF EVIDENTIAL IMPOSSIBILITY: A PROPOSITION, P, IS EVIDENTIALLY IMPOSSIBLE IF AND ONLY IF ALLEGED EVIDENCE FOR THE TRUTH OF P WOULD NOT BE EVIDENCE FOR P, WERE (...) THE TRUTH OF P ESTABLISHED. I ARGUE THAT HUME’S CLAIM, WHICH IS THAT PROPOSITIONS ASSERTING THE EXISTENCE OF MIRACLES ARE EVIDENTIALLY IMPOSSIBLE, IS ONE WHICH IS NOT ACCEPTABLE, BUT FOR REASONS OTHER THAN THOSE THAT ARE USUALLY GIVEN. (shrink)

pThis article seeks to demonstrate how a dialogue between literary theorist and psychoanalyst François Flahault and Kyoto School philosopher Nishida Kitarō can be mutually beneficial in the service of building an account of good and evil that contributes to discourses in ethics. Although Flahault and Nishida share a similar commitment to disrupt the dichotomy between good and evil in the effort to liberate subjectivity, they diverge in terms of how their accounts relate subjectivity to the processes of social history. As (...) this article will discuss, the significance of their divergence, however, elucidates the strengths and limits of their approaches to the victim-victimizer duality that is implied within the problem of good and evil. Such a divergence also points to a potential space of synthesis and mutual enrichment as well: namely, on the side of championing Nishida’s contradictory logic and Flahault’s emphasis on the contextual demands and problems of social history. That is to say, within the dialogical encounter between Flahault and Nishida, as the present article suggests, is the potentiality to develop a universal conception of the common good that is contradictorily linked to the subjective interior where such provides a critical resource for a deeper engagement with the victim-victimizer duality./p. (shrink)